Preclinical Data

SAP Mechanism of Action

Arch’s initial products to market will be in the AC5™ family. AC5™ Topical Gel is a self-assembling peptide (SAP) comprising naturally-occurring amino acids. The technology has shown promise in various barrier applications for hemostatic effect, control of substance movement, and prevention of adhesions, as well as in nerve and other tissue regeneration, where the nanoscale scaffold-like structure of the barrier provides a microenvironment that allows normal wound healing

When applied onto a wound, AC5™ rapidly intercalates into the nooks and crannies of the tissue as it builds itself into a physical, mechanical wound-filling structure.


SAP (A) contacts wound’s ionic charge (B) and assembles into a nanofiber network (C) that gels while it fills the wound  (D) * = areas of intercalation) into connective tissue forming mechanical-physical barrier to fluids, bacteria, etc., 

Pre-Clinical Studies

SAP Technology
  • Worked equally well in heparinized or control animals, and animals with/without antiplatelet agents.


  • Worked equally well in heparinized or control animals, and animals with/without antiplatelet agents.


  • Demonstrated hemostatic properties in liver and other organs in in vivo surgical models, including durable hemostasis within15 seconds. SAP compositions have been tested in small animal organs (i.e. liver, skin, muscle, brain, eye, spine, spleen, arteries and veins). In mammalian vision models (severed hamster optic tract), SAPs have demonstrated reversal of blindness by providing a scaffold to allow regenerated axons to connect to target tissues.

    In ocular tissue pilot studies, SAPs demonstrated biocompatibility and the ability to rapidly and reliably stop bleeding (Figure ) and limit inflammation.


    Hemostatic effect in ocular application
    Sclera of a rat eye (A) is punctured with a syringe at the limbal artery (B) and bleeds profusely (C). The eye is then treated with SAP (D). Bleeding stopped in 8 seconds and remained stopped for the duration of the observation (15 minutes). Pressure applied to the cornea did not dislodge the material from the sclera (F). Hemostasis was maintained even with repeated manipulation of the eye. Ellis-Behnke R, Liang Y-X, You SW, et al. PNAS 2006;1033:5054–9. Data on file, Arch Therapeutics.